Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4664198 | 0.87 | MAPT (0.40) | MAPTHPGDKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4772562 | 0.87 | MAPT (0.44) | MAPTHPGDKDM4ESMN1; SMN2TP53 | |
| SCHEMBL5141389 | 0.87 | MAPT (0.44) | MAPTHPGDKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4778613 | 0.81 | KMT2A (0.57) | MAPTHPGDKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4662905 | 0.80 | PLK1 (0.47) | MAPTHPGDKDM4EALDH1A1TP53 | |
| SCHEMBL4198064 | 0.80 | MAPT (0.39) | MAPTHPGDKDM4ESMN1; SMN2TP53 | |
| SCHEMBL4662743 | 0.79 | MAPT (0.43) | MAPTHPGDKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6210332 | 0.74 | PLK1 (0.56) | — | |
| SCHEMBL1813590 | 0.74 | KDM4E (0.46) | MAPTHPGDKDM4EMRGPRX4LMNA | |
| SCHEMBL577918 | 0.72 | PLK1 (0.46) | MAPTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007757-A2 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | Vertex Pharmceuticals Incorporated (US) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007120760-A2 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-25 | — | — | WO | disclosed |