Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4664301 | 0.81 | MAPT (0.45) | KMT2AMEN1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL5141389 | 0.80 | MAPT (0.44) | KMT2AMEN1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL4772562 | 0.80 | MAPT (0.44) | KMT2AMEN1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL2453740 | 0.78 | KMT2A (0.64) | KMT2AMEN1CYP1A2SMN1; SMN2MAPT | |
| SCHEMBL20505231 | 0.77 | KMT2A (0.77) | KMT2AMEN1CYP1A2SMN1; SMN2MAPT | |
| SCHEMBL9667534 | 0.76 | KMT2A (0.74) | KMT2AMEN1CYP1A2MAPTKDM4E | |
| SCHEMBL28272334 | 0.76 | KMT2A (0.69) | KMT2AMEN1CYP1A2SMN1; SMN2MAPT | |
| SCHEMBL4331526 | 0.73 | KMT2A (1.00) | KMT2AMEN1CYP1A2SMN1; SMN2MAPT | |
| SCHEMBL9580689 | 0.73 | KMT2A (0.70) | KMT2AMEN1CYP1A2MAPTHPGD | |
| SCHEMBL2498156 | 0.73 | KMT2A (0.66) | KMT2AMEN1CYP1A2SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989205-A2 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | Vertex Pharmceuticals Incorporated (US) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007087283-A2 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-08-02 | — | — | WO | disclosed |