Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CES1 | P23141 | 3/20 | 0.43 |
| ▸ | CES2 | O00748 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.41 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylene Chloride SCHEMBL11140953 | 0.94 | — | — | |
| Alcohol SCHEMBL6384641 | 0.91 | — | — | |
| SCHEMBL10577 | 0.85 | — | — | |
| SCHEMBL865687 | 0.85 | — | — | |
| SCHEMBL876374 | 0.85 | ALDH1A1 (0.64) | ALDH1A1TSHRCES1CES2HDAC3 | |
| SCHEMBL7626853 | 0.82 | — | — | |
| SCHEMBL7629714 | 0.82 | — | — | |
| SCHEMBL7628130 | 0.82 | — | — | |
| SCHEMBL21835093 | 0.82 | — | — | |
| SCHEMBL7625051 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1666924-B1 | Covalently-bound hydrophilic coating compositions for implants | ALCON INC (CH) | 2008-12-10 | — | — | EP | disclosed |
| EP-1208393-B1 | COVALENTLY-BOUND, HYDROPHILIC COATING COMPOSITIONS FOR IMPLANTS | ALCON INC (CH) | 2008-10-08 | — | — | EP | disclosed |
| EP-1666924-A2 | Covalently-bound, hydrophilic coating compositions for surgical implants | Alcon, Inc (CH) | 2006-06-07 | — | — | EP | disclosed |
| US-6723815-B2 | INTRAOCULAR LENSES AND CONTACT LENSES; HYDROPHOBIC ARYL ACRYLIC MONOMER, A HYDROPHILIC MONOMER SELECTED FROM HYDROXYALKYL (METH)ACRYLATES, N-VINYL PYRROLIDONE AND ACRYLAMIDES, AND A REACTIVE PLASTICIZER | ALCON, INC. (CH) | 2004-04-20 | — | — | US | disclosed |
| US-20030208013-A1 | Covalently-bound, hydrophilic coating compositions for surgical implants | ALCON INC. (CH) | 2003-11-06 | — | — | US | disclosed |
| US-6632905-B2 | For ophthalmic implants comprising silicone, hydrophobic acrylic or hydrogel materials | ALCON UNIVERSAL LTD. (CH) | 2003-10-14 | — | — | US | disclosed |
| US-20020082372-A1 | Covalently-bound, hydrophilic coating compositions for surgical implants | ALCON INC. (CH) | 2002-06-27 | — | — | US | disclosed |
| EP-1208393-A1 | COVALENTLY-BOUND, HYDROPHILIC COATING COMPOSITIONS FOR IMPLANTS | Alcon Universal, Ltd. (CH) | 2002-05-29 | — | — | EP | disclosed |
| WO-2001016626-A1 | COVALENTLY-BOUND, HYDROPHILIC COATING COMPOSITIONS FOR IMPLANTS | ALCON UNIVERSAL LTD. (CH) | 2001-03-08 | — | — | WO | disclosed |