Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.31 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
| ▸ | DHFR | P00374 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4664643 | 0.89 | CXCR2 (0.33) | KDM4EALDH1A1LMNACXCR2CXCR1 | |
| SCHEMBL4662901 | 0.89 | CXCR2 (0.33) | KDM4EALDH1A1LMNACXCR2CXCR1 | |
| SCHEMBL5138943 | 0.89 | CXCR2 (0.33) | KDM4EALDH1A1LMNACXCR2CXCR1 | |
| SCHEMBL4664676 | 0.87 | CXCR2 (0.34) | KDM4EALDH1A1CXCR2CXCR1NPC1 | |
| SCHEMBL4664660 | 0.85 | NPC1 (0.33) | KDM4EALDH1A1CXCR2CXCR1NPC1 | |
| SCHEMBL4664836 | 0.84 | PARP1 (0.35) | KDM4EALDH1A1LMNACXCR2CXCR1 | |
| SCHEMBL4663226 | 0.84 | KMT2A (0.33) | PDK1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL5107986 | 0.81 | AOC3 (0.37) | MEN1KMT2AHIF1A | |
| SCHEMBL5107989 | 0.81 | AOC3 (0.37) | MEN1KMT2AHIF1A | |
| SCHEMBL5106851 | 0.79 | AOC3 (0.32) | KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113963-A1 | Cyclic benzimidazoles | ALTANA PHARMA AG (DE) | 2008-05-15 | — | — | US | disclosed |
| US-7307084-B2 | Cyclic benzimidazoles | ALTANA PHARMA AG (DE) | 2007-12-11 | — | — | US | disclosed |
| US-20060194968-A1 | Cyclic benizimidazoles | ALTANA PHARMA AG (DE) | 2006-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194968-A1 | Cyclic benizimidazoles | VIP, SI, GIPR | PDK1 435/4885KDM4E 1927/4885ALDH1A1 293/4885 |
| US-20080113963-A1 | Cyclic benzimidazoles | VIP, GIPR, SI | PDK1 1317/4885KDM4E 3472/4885ALDH1A1 2588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.