Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.62 |
| ▸ | MIF | P14174 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
| ▸ | HTR2B | P41595 | 3/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | ACP3 | P15309 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | DAO | P14920 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11383498 | 0.83 | TAAR1 (0.65) | TAAR1MIFHDAC1HDAC8IDO1 | |
| SCHEMBL81245 | 0.81 | TAAR1 (0.62) | TAAR1MIFHDAC1HDAC8IDO1 | |
| SCHEMBL21913967 | 0.81 | TAAR1 (0.62) | TAAR1MIFHDAC1HDAC8IDO1 | |
| SCHEMBL2090576 | 0.81 | TAAR1 (0.62) | TAAR1MIFHDAC1HDAC8IDO1 | |
| SCHEMBL386982 | 0.81 | TAAR1 (0.62) | TAAR1MIFHDAC1HDAC8IDO1 | |
| SCHEMBL1723183 | 0.81 | TAAR1 (0.62) | TAAR1MIFHDAC1HDAC8IDO1 | |
| SCHEMBL1045499 | 0.81 | TAAR1 (0.62) | TAAR1MIFHDAC1HDAC8IDO1 | |
| SCHEMBL1046263 | 0.81 | TAAR1 (0.62) | TAAR1MIFHDAC1HDAC8IDO1 | |
| SCHEMBL365289 | 0.81 | TAAR1 (0.79) | TAAR1MIFHDAC1HDAC8IDO1 | |
| SCHEMBL31543288 | 0.81 | TAAR1 (0.62) | TAAR1MIFHDAC1HDAC8IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928817-A1 | PROCESS FOR THE PREPARATION OF CINACALCET BASE | Teva Pharmaceutical Industries Ltd (IL) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007127449-A1 | PROCESS FOR THE PREPARATION OF CINACALCET BASE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-11-08 | — | — | WO | disclosed |