Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 6/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | GRK5 | P34947 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6030794 | 0.89 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL6030791 | 0.89 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL5046005 | 0.87 | HDAC3 (0.59) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL5046007 | 0.87 | HDAC3 (0.59) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL6030810 | 0.87 | HDAC3 (0.76) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL6030805 | 0.87 | HDAC3 (0.76) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL4664626 | 0.83 | HDAC3 (0.51) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL1588287 | 0.81 | NPSR1 (0.51) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL4463963 | 0.81 | HDAC3 (0.53) | HDAC3HDAC4HDAC1HDAC6HDAC7 | |
| SCHEMBL5042488 | 0.80 | HDAC1 (0.51) | HDAC3HDAC4HDAC1HDAC6HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423060-B2 | Thiophene hydroxamic acid derivatives and their use as HDAC inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2008-09-09 | — | — | US | disclosed |
| US-20080070976-A1 | Thiophene Hydroxamic Acid Derivatives and Their Use as Hdac Inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070976-A1 | Thiophene Hydroxamic Acid Derivatives and Their Use as Hdac Inhibitors | HDAC1, HDAC5, HDAC2 | HDAC3 8/4885HDAC4 7/4885HDAC1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.