Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 4/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | PHGDH | O43175 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6030791 | 0.83 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC6LMNA | |
| SCHEMBL6030794 | 0.83 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC6LMNA | |
| SCHEMBL4664658 | 0.83 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC6LMNA | |
| SCHEMBL5046005 | 0.82 | HDAC3 (0.59) | HDAC3HDAC4HDAC1HDAC6POLB | |
| SCHEMBL5046007 | 0.82 | HDAC3 (0.59) | HDAC3HDAC4HDAC1HDAC6POLB | |
| SCHEMBL6030805 | 0.81 | HDAC3 (0.76) | HDAC3HDAC4HDAC1HDAC6POLB | |
| SCHEMBL6030810 | 0.81 | HDAC3 (0.76) | HDAC3HDAC4HDAC1HDAC6POLB | |
| SCHEMBL6984561 | 0.77 | ALDH1A1 (0.54) | LMNASMN1; SMN2ALDH1A1L3MBTL1MEN1 | |
| SCHEMBL1588287 | 0.76 | NPSR1 (0.51) | HDAC3HDAC4HDAC1HDAC6POLB | |
| SCHEMBL4463963 | 0.76 | HDAC3 (0.53) | HDAC3HDAC4HDAC1HDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423060-B2 | Thiophene hydroxamic acid derivatives and their use as HDAC inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2008-09-09 | — | — | US | disclosed |
| US-20080070976-A1 | Thiophene Hydroxamic Acid Derivatives and Their Use as Hdac Inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070976-A1 | Thiophene Hydroxamic Acid Derivatives and Their Use as Hdac Inhibitors | HDAC1, HDAC5, HDAC2 | HDAC3 8/4885HDAC4 7/4885HDAC1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.