Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.36 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 5/20 | 0.36 |
| ▸ | PPARA | Q07869 | 5/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4665016 | 0.85 | HTT (0.48) | ALDH1A1KDM4EHPGDHSD17B10JAK2 | |
| SCHEMBL4664870 | 0.85 | TLR9 (0.38) | ALDH1A1KDM4EHPGDHSD17B10JAK2 | |
| SCHEMBL4666734 | 0.85 | IKBKB (0.48) | ALDH1A1KDM4EHPGDHSD17B10JAK2 | |
| SCHEMBL3989409 | 0.85 | IKBKB (0.46) | JAK2TLR9TLR8TLR7JAK1 | |
| SCHEMBL4664952 | 0.82 | IKBKB (0.51) | KDM4EJAK2 | |
| SCHEMBL3988315 | 0.79 | TLR9 (0.40) | ALDH1A1KDM4EHPGDHSD17B10JAK2 | |
| SCHEMBL3987328 | 0.78 | MAP4K4 (0.39) | JAK2TLR9TLR8TLR7GPR119 | |
| SCHEMBL4663358 | 0.78 | IKBKB (0.43) | JAK2 | |
| SCHEMBL3989890 | 0.77 | TLR9 (0.39) | ALDH1A1KDM4EHSD17B10JAK2TLR9 | |
| SCHEMBL3994799 | 0.76 | TLR9 (0.38) | JAK2TLR9TLR8TLR7GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940296-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007114848-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-10-11 | — | — | WO | disclosed |