Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.74 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.74 |
| ▸ | CNR1 | P21554 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.51 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | IL18 | Q14116 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4116856 | 0.86 | MAPT (1.00) | MAPTLMNATSHRHTTNLRP3 | |
| SCHEMBL10668018 | 0.77 | IDO1 (0.55) | MAPTLMNATSHRHTTNLRP3 | |
| SCHEMBL11054945 | 0.77 | MAPT (0.81) | MAPTLMNATSHRHTTNLRP3 | |
| SCHEMBL20941635 | 0.76 | MAPT (0.75) | MAPTLMNATSHRHTTNLRP3 | |
| SCHEMBL11236184 | 0.75 | NPC1 (0.50) | MAPTLMNATSHRHTTNLRP3 | |
| SCHEMBL21645391 | 0.74 | IDO1 (0.50) | MAPTLMNATSHRHTTNLRP3 | |
| SCHEMBL16872738 | 0.74 | CNR1 (0.49) | CNR1ALDH1A1RAB9A | |
| SCHEMBL4349313 | 0.74 | MAPT (0.70) | MAPTLMNATSHRHTTNLRP3 | |
| SCHEMBL13097207 | 0.74 | MAPT (0.51) | MAPTLMNATSHRHTTNLRP3 | |
| SCHEMBL22834250 | 0.73 | CNR1 (1.00) | MAPTLMNATSHRHTTNLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888626-A2 | A THERAPEUTIC AGENT FOR AB RELATED DISORDERS | Eisai R&D Management Co., Ltd. (JP) | 2008-02-20 | — | — | EP | disclosed |
| US-20060241038-A1 | Therapeutic agent for Abeta related disorders | EISAI CO., LTD. (JP) | 2006-10-26 | — | — | US | disclosed |
| WO-2006112550-A2 | A THERAPEUTIC AGENT FOR Aβ RELATED DISORDERS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2006-10-26 | — | — | WO | disclosed |
| WO-2006112551-A2 | A THERAPEUTIC AGENT FOR Aβ RELATED DISORDERS | EISAI CO., LTD. (JP) | 2006-10-26 | — | — | WO | disclosed |
| WO-2006112552-A2 | THERAPEUTIC AGENTS FOR ABETA RELATED DISORDERS | EISAI CO., LTD. (JP) | 2006-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241038-A1 | Therapeutic agent for Abeta related disorders | APP, BACE1, PSEN1 | MAPT 9/4885LMNA 2088/4885TSHR 4455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.