Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.31 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 2/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4660631 | 0.92 | NR1H4 (0.48) | NR1H4KMT2AATMCTSD | |
| SCHEMBL5274004 | 0.89 | NR1H4 (0.47) | NR1H4KMT2AATMELANE | |
| SCHEMBL4627449 | 0.88 | NR1H4 (0.39) | NR1H4KMT2AATMALDH1A1NPSR1 | |
| SCHEMBL6449480 | 0.88 | NR1H4 (0.43) | NR1H4CTSDELANE | |
| SCHEMBL4662900 | 0.85 | NR1H4 (0.42) | NR1H4CTSDELANE | |
| SCHEMBL5689551 | 0.83 | NR1H4 (0.51) | NR1H4KMT2AATMCTSDELANE | |
| SCHEMBL4596921 | 0.82 | NR1H4 (0.50) | NR1H4KMT2AATMCTSDELANE | |
| SCHEMBL4780637 | 0.82 | NR1H4 (0.48) | NR1H4KMT2AATMCTSD | |
| SCHEMBL4637119 | 0.81 | NR1H4 (0.47) | NR1H4KMT2AATM | |
| SCHEMBL4778440 | 0.81 | NR1H4 (0.38) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877067-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONE GLUCURONIDE DERIVATIVES FOR HYPERCHOLESTEROLEMIA | Microbia, Inc. (US) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006116499-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONE GLUCURONIDE DERIVATIVES FOR HYPERCHOLESTEROLEMIA | MICROBIA, INC. (US) | 2006-11-02 | — | — | WO | disclosed |
| EP-1675820-A2 | PROPIONIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF LIPID DISORDERS | AstraZeneca AB (SE) | 2006-07-05 | — | — | EP | disclosed |
| EP-1610770-A1 | USE OF AN IBAT INHIBITOR FOR THE TREATMENT OF PROPHYLAXIS OF CONSTIPATION | AstraZeneca AB (SE) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004113270-A2 | PROPIONIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF LIPID DISORDERS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | disclosed |
| WO-2004089350-A1 | USE OF AN IBAT INHIBITOR FOR THE TREATMENT OF PROPHYLAXIS OF CONSTIPATION | ASTRAZENECA AB (SE) | 2004-10-21 | — | — | WO | disclosed |