Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 15/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4367348 | 1.00 | HSD11B1 (0.55) | HSD11B1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL15151349 | 1.00 | HSD11B1 (0.55) | HSD11B1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL15151353 | 1.00 | HSD11B1 (0.55) | HSD11B1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL4370589 | 1.00 | HSD11B1 (0.55) | HSD11B1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL4368782 | 0.88 | HSD11B1 (0.56) | HSD11B1CYP3A4SMN1; SMN2 | |
| SCHEMBL4367498 | 0.88 | SMN1; SMN2 (0.46) | HSD11B1CYP3A4SMN1; SMN2 | |
| SCHEMBL4366452 | 0.87 | HSD11B1 (0.46) | HSD11B1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL4363332 | 0.87 | HSD11B1 (0.44) | HSD11B1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL4363453 | 0.86 | HSD11B1 (0.44) | HSD11B1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL4376905 | 0.86 | HSD11B1 (0.60) | HSD11B1CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924563-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1-INHIBITOR-DIABETES-TYPE 2-1 | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025892-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1-INHIBITOR-DIABETES-TYPE 2-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |
| US-4720487-A | Bornane derivatives, their preparation and therapeutic compositions containing the same | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1988-01-19 | — | — | US | disclosed |