Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.57 |
| ▸ | CTSB | P07858 | 17/20 | 0.57 |
| ▸ | CTSD | P07339 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4666885 | 0.93 | BACE1 (0.58) | BACE1CTSBCTSD | |
| SCHEMBL4664372 | 0.88 | BACE1 (0.64) | BACE1CTSBCTSD | |
| SCHEMBL4664363 | 0.88 | BACE1 (0.64) | BACE1CTSBCTSD | |
| SCHEMBL4664415 | 0.87 | BACE1 (0.59) | BACE1CTSBCTSD | |
| SCHEMBL4666851 | 0.86 | BACE1 (0.59) | BACE1CTSBCTSD | |
| SCHEMBL4666849 | 0.85 | BACE1 (0.60) | BACE1CTSBCTSD | |
| SCHEMBL4665107 | 0.85 | BACE1 (0.62) | BACE1CTSBCTSD | |
| SCHEMBL4666390 | 0.85 | BACE1 (0.60) | BACE1CTSBCTSD | |
| SCHEMBL4665101 | 0.85 | BACE1 (0.62) | BACE1CTSBCTSD | |
| SCHEMBL14348090 | 0.85 | CTSB (0.73) | BACE1CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395551-B1 | HYDROXY ALKYL AMINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND THEIR USE FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND SIMILAR DISEASES | ELAN PHARM INC (US) | 2008-05-21 | — | — | EP | claimed |