Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 18/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377588 | 1.00 | HSD11B1 (0.73) | HSD11B1CYP3A4ALDH1A1 | |
| SCHEMBL4371965 | 0.87 | HSD11B1 (0.81) | HSD11B1CYP3A4ALDH1A1 | |
| SCHEMBL4363509 | 0.85 | HSD11B1 (1.00) | HSD11B1CYP3A4 | |
| SCHEMBL15151458 | 0.85 | HSD11B1 (1.00) | HSD11B1CYP3A4 | |
| SCHEMBL4376764 | 0.85 | HSD11B1 (1.00) | HSD11B1CYP3A4 | |
| SCHEMBL4370765 | 0.85 | HSD11B1 (1.00) | HSD11B1CYP3A4 | |
| SCHEMBL4371680 | 0.82 | HSD11B1 (0.81) | HSD11B1CYP3A4ALDH1A1 | |
| SCHEMBL4664014 | 0.81 | HSD11B1 (1.00) | HSD11B1CYP3A4ALDH1A1 | |
| SCHEMBL4367317 | 0.81 | HSD11B1 (1.00) | HSD11B1CYP3A4ALDH1A1 | |
| SCHEMBL4665257 | 0.80 | HSD11B1 (0.79) | HSD11B1CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924563-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1-INHIBITOR-DIABETES-TYPE 2-1 | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007025892-A1 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1-INHIBITOR-DIABETES-TYPE 2-1 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |