SCHEMBL4666868

SCHEMBL4666868

CC(O[Si](C)(C)C)(c1ccccc1)C(C)(O[Si](C)(C)C)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.46
ALDH1A1 P00352 3/20 0.43
ALOX15 P16050 1/20 0.43
TAAR1 Q96RJ0 1/20 0.38
ESR1 P03372 2/20 0.37
ESR2 Q92731 2/20 0.37
CYP3A4 P08684 2/20 0.37
KCNN4 O15554 4/20 0.36
MAPT P10636 1/20 0.35
KMT2A Q03164 1/20 0.35
TSHR P16473 3/20 0.35
CYP2C19 P33261 2/20 0.34
HIF1A Q16665 1/20 0.34
KCNA5 P22460 1/20 0.34
CYP2B6 P20813 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8926005 0.82 MAPT (0.40) MAPK1ALDH1A1ALOX15KCNN4MAPT
SCHEMBL14292070 0.81 MAPK1 (0.46) MAPK1ALDH1A1ALOX15TAAR1ESR1
SCHEMBL11074528 0.78 KCNN4 (0.51) MAPK1ALDH1A1ALOX15KCNN4MAPT
SCHEMBL4629554 0.78 MAPK1 (0.42) MAPK1ALDH1A1ALOX15TAAR1ESR1
SCHEMBL3118068 0.78 MAPK1 (0.42) MAPK1ALDH1A1ALOX15TAAR1ESR1
SCHEMBL7178758 0.77 MAPK1 (0.43) MAPK1ALDH1A1ALOX15TAAR1ESR1
SCHEMBL21810501 0.77 MAPK1 (0.48) MAPK1ALDH1A1ALOX15TAAR1ESR1
SCHEMBL10881380 0.76 MAPK1 (0.41) MAPK1ALDH1A1ALOX15TAAR1ESR1
SCHEMBL14360753 0.74 MAPK1 (0.40) MAPK1ALDH1A1ALOX15TAAR1ESR1
SCHEMBL2452793 0.74 MAPK1 (0.40) MAPK1ALDH1A1ALOX15TAAR1ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1497372-B1 THERMOSET COMPOSITION, METHOD AND ARTICLE GEN ELECTRIC (US) 2007-01-17 EP claimed
US-6967229-B2 Carbon-carbon initiators for use in golf balls ACUSHNET COMPANY (US) 2005-11-22 US claimed
US-20050009992-A1 Carbon-carbon initiators for use in golf balls JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT 2005-01-13 US claimed
EP-1165690-B1 CURABLE RESIN COMPOSITION, METHOD FOR THE PREPARATION THEREOF, AND ARTICLES DERIVED THEREFROM GEN ELECTRIC (US) 2004-12-15 EP claimed
US-9056227-B2 Golf ball comprising a core having a shallow hardness gradient ACUSHNET COMPANY (US) 2015-06-16 US disclosed
US-8968117-B2 Dual-core comprising zero gradient center and positive gradient outer core layer ACUSHNET COMPANY (US) 2015-03-03 US disclosed
CN-101268522-B Method of electrical insulation by coating poly (arylene ether) composition and insulated electrical conductor GEN ELECTRIC 2014-09-17 CN disclosed
CN-103877703-A Dual-Core Comprising Zero Gradient Center And Positive Gradient Outer Core Layer ACUSHNET CO 2014-06-25 CN disclosed
US-20130109506-A1 GOLF BALL COMPRISING A CORE HAVING A SHALLOW HARDNESS GRADIENT ACUSHNET COMPANY (US) 2013-05-02 US disclosed
US-20130109504-A1 DUAL-CORE COMPRISING ZERO GRADIENT CENTER AND POSITIVE GRADIENT OUTER CORE LAYER ACUSHNET COMPANY (US) 2013-05-02 US disclosed
EP-1941518-A1 METHOD FOR ELECTRICAL INSULATION VIA APPLYING A POLY (ARYLENE ETHER) COMPOSITION AND INSULATED ELECTRICAL CONDUCTOR General Electric Company (US) 2008-07-09 EP disclosed
WO-2007037940-A1 METHOD FOR ELECTRICAL INSULATION VIA APPLYING A POLY (ARYLENE ETHER) COMPOSITION AND INSULATED ELECTRICAL CONDUCTOR GENERAL ELECTRIC COMPANY (US) 2007-04-05 WO disclosed
US-20070066710-A1 Method for electrical insulation and insulated electrical conductor CITIBANK, N.A., AS COLLATERAL AGENT 2007-03-22 US disclosed
US-20060038324-A1 Molding method for curable poly(arylene ether) composition and article thereby CITIBANK, N.A., AS COLLATERAL AGENT 2006-02-23 US disclosed
US-6967229-B2 Carbon-carbon initiators for use in golf balls ACUSHNET COMPANY (US) 2005-11-22 US disclosed
US-20050009992-A1 Carbon-carbon initiators for use in golf balls JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT 2005-01-13 US disclosed