Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 1/20 | 0.52 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.52 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | ABAT | P80404 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21118237 | 0.89 | HRH3 (0.54) | CARM1PRMT6PRMT8KDM4EALDH1A1 | |
| SCHEMBL24508725 | 0.86 | KDM4E (0.53) | CARM1PRMT6PRMT8KDM4EALDH1A1 | |
| SCHEMBL2206045 | 0.86 | HRH3 (0.46) | CARM1PRMT6PRMT8KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL2202973 | 0.84 | CXCR4 (0.45) | CARM1PRMT6PRMT8KDM4EALDH1A1 | |
| SCHEMBL3152090 | 0.83 | MAPT (0.58) | CARM1PRMT6PRMT8KDM4EALDH1A1 | |
| SCHEMBL16550458 | 0.83 | KDM4E (0.53) | CARM1PRMT6PRMT8KDM4EALDH1A1 | |
| SCHEMBL1636366 | 0.82 | TSHR (0.45) | CARM1PRMT6PRMT8KDM4EALDH1A1 | |
| SCHEMBL13078725 | 0.81 | HRH3 (0.69) | HRH3MAPT | |
| SCHEMBL1206737 | 0.81 | HRH3 (0.53) | HRH3MAPTSIGMAR1 | |
| SCHEMBL14430280 | 0.80 | CARM1 (0.53) | CARM1PRMT6PRMT8KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924561-A2 | 6-ARYLALKYLAMINO- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | Eli Lilly & Company (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007028083-A2 | 6-ARYLALKYLAMINO- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2007-03-08 | — | — | WO | disclosed |