Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.31 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3122960 | 0.91 | FFAR4 (0.38) | FFAR4HRH3PARP1PARP2MEN1 | |
| SCHEMBL15295228 | 0.81 | HRH3 (0.38) | FFAR4HRH3PARP1PARP2TTR | |
| SCHEMBL5314384 | 0.81 | FFAR4 (0.36) | FFAR4HRH3PARP1PARP2EGLN2 | |
| SCHEMBL23588303 | 0.80 | HRH3 (0.40) | FFAR4HRH3 | |
| SCHEMBL31255629 | 0.80 | HRH3 (0.38) | FFAR4HRH3PARP1PARP2EGLN2 | |
| SCHEMBL10764567 | 0.78 | PLAU (0.34) | MEN1TTRALBKMT2AGSK3B | |
| SCHEMBL3119850 | 0.77 | HRH3 (0.40) | HRH3EGLN2GSK3B | |
| SCHEMBL15292532 | 0.77 | HRH3 (0.36) | FFAR4HRH3PARP1PARP2 | |
| SCHEMBL5018947 | 0.77 | TRPV4 (0.38) | FFAR4HRH3TTRALB | |
| SCHEMBL5425809 | 0.74 | MAPT (0.40) | FFAR4HRH3MEN1KMT2AEGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893619-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTMIAS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006135316-A1 | New oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |