Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25664000 | 1.00 | PIK3CD (0.47) | PIK3CDKDM4EALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL25663999 | 1.00 | PIK3CD (0.47) | PIK3CDKDM4EALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL25664008 | 0.89 | KMT2A (0.48) | PIK3CDKDM4EALDH1A1TDP1KMT2A | |
| SCHEMBL25664007 | 0.89 | KMT2A (0.48) | PIK3CDKDM4EALDH1A1TDP1KMT2A | |
| SCHEMBL13312886 | 0.89 | PIK3CD (0.55) | PIK3CDKDM4EALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL12443041 | 0.85 | POLB (0.47) | PIK3CDKDM4EALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL12000479 | 0.84 | PIK3CD (0.48) | PIK3CDKDM4EALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL14155739 | 0.84 | SMN1; SMN2 (0.55) | PIK3CDKDM4EALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL14155738 | 0.84 | SMN1; SMN2 (0.55) | PIK3CDKDM4EALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL25664037 | 0.84 | ARG1 (0.39) | PIK3CDKDM4EALDH1A1SMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230143612-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA CORP (US) | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230143612-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | HAVCR2, HMBS, VHL | PIK3CD 2759/4885KDM4E 224/4885ALDH1A1 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.