Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4128011 | 0.87 | KCNH2 (0.47) | KCNH2KDM4EHRH3FFAR4ALDH1A1 | |
| SCHEMBL4128894 | 0.86 | KCNH2 (0.46) | KCNH2KDM4EHRH3FFAR4KCNA5 | |
| SCHEMBL4133428 | 0.83 | KCNH2 (0.49) | KCNH2KDM4EHRH3FFAR4ALDH1A1 | |
| SCHEMBL1619360 | 0.82 | KCNH2 (0.39) | KCNH2KDM4EHRH3FFAR4KCNA5 | |
| SCHEMBL2968099 | 0.82 | KCNA5 (0.54) | KCNH2KDM4EHRH3KCNA5ALDH1A1 | |
| SCHEMBL4669350 | 0.81 | KCNH2 (0.49) | KCNH2KDM4EHRH3ALDH1A1HTT | |
| SCHEMBL4125759 | 0.81 | KCNH2 (0.51) | KCNH2KDM4EHRH3FFAR4ALDH1A1 | |
| SCHEMBL4418109 | 0.79 | KDM4E (0.41) | KCNH2KDM4EKCNA5ALDH1A1TDP1 | |
| SCHEMBL1619386 | 0.78 | HRH3 (0.44) | KCNH2KDM4EHRH3FFAR4ALDH1A1 | |
| SCHEMBL1619503 | 0.78 | HRH3 (0.44) | KCNH2KDM4EHRH3FFAR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893619-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTMIAS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006135316-A1 | New oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |