Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1619503 | 0.95 | HRH3 (0.44) | KCNH2HRH3KDM4EFFAR4ALDH1A1 | |
| SCHEMBL1619386 | 0.92 | HRH3 (0.44) | KCNH2HRH3KDM4EFFAR4ALDH1A1 | |
| SCHEMBL1619062 | 0.88 | HRH3 (0.43) | KCNH2HRH3KDM4EALDH1A1TDP1 | |
| SCHEMBL1619357 | 0.84 | HRH3 (0.48) | KCNH2HRH3KDM4EALDH1A1HTT | |
| SCHEMBL1619395 | 0.83 | HRH3 (0.45) | KCNH2HRH3KDM4EALDH1A1HTT | |
| SCHEMBL4667626 | 0.82 | KCNH2 (0.42) | KCNH2HRH3KDM4EFFAR4ALDH1A1 | |
| SCHEMBL1619052 | 0.80 | HRH3 (0.48) | KCNH2HRH3KDM4EALDH1A1HTT | |
| SCHEMBL4128894 | 0.80 | KCNH2 (0.46) | KCNH2HRH3KDM4EFFAR4ALDH1A1 | |
| SCHEMBL1619682 | 0.80 | KCNH2 (0.45) | KCNH2HRH3KDM4EALDH1A1TDP1 | |
| SCHEMBL1618052 | 0.79 | KCNH2 (0.48) | KCNH2HRH3KDM4EHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928225-B2 | Oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2011-04-19 | — | — | US | disclosed |