Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 14/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 12/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL589466 | 1.00 | ADORA2A (0.54) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL5225967 | 1.00 | ADORA2A (0.54) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL1415176 | 1.00 | ADORA2A (0.54) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL1415177 | 1.00 | ADORA2A (0.54) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL2812121 | 0.94 | ADORA3 (0.53) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL4668885 | 0.94 | ADORA2A (0.47) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL590422 | 0.94 | ADORA2A (0.47) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL3143055 | 0.94 | ADORA2A (0.47) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL590340 | 0.92 | ADORA2A (0.55) | ADORA2AADORA3ADORA1ADORA2B | |
| SCHEMBL2807840 | 0.88 | ADORA3 (0.46) | ADORA2AADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841768-B1 | PURINE DERIVATIVES ACTING AS A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2008-11-12 | — | — | EP | disclosed |