Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 10/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 13/20 | 0.44 |
| ▸ | AURKA | O14965 | 9/20 | 0.44 |
| ▸ | TPX2 | Q9ULW0 | 6/20 | 0.44 |
| ▸ | KDR | P35968 | 6/20 | 0.39 |
| ▸ | LCK | P06239 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668273 | 0.88 | AURKB (0.48) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL4666642 | 0.81 | TEK (0.45) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL581299 | 0.76 | TEK (0.42) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL580771 | 0.74 | TEK (0.46) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL4668267 | 0.74 | TEK (0.46) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL4669544 | 0.73 | TEK (0.51) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL4668531 | 0.73 | TEK (0.41) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL580385 | 0.73 | TEK (0.60) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL5318988 | 0.72 | TEK (0.55) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL580716 | 0.71 | AURKB (0.54) | TEKAURKBAURKATPX2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087276-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2007-08-02 | — | — | WO | disclosed |