Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668434 | 1.00 | EGFR (0.51) | EGFRERBB2PRMT5PKMERN1 | |
| SCHEMBL4135023 | 0.93 | PRMT5 (0.47) | EGFRERBB2PRMT5IGF1R | |
| SCHEMBL4133629 | 0.91 | PRMT5 (0.44) | EGFRERBB2PRMT5PKMIGF1R | |
| SCHEMBL4133627 | 0.91 | PRMT5 (0.44) | EGFRERBB2PRMT5PKMIGF1R | |
| SCHEMBL4122888 | 0.85 | EGFR (0.50) | EGFRERBB2PRMT5LMNAHPGD | |
| SCHEMBL4122891 | 0.85 | EGFR (0.50) | EGFRERBB2PRMT5LMNAHPGD | |
| SCHEMBL4635258 | 0.80 | EGFR (0.48) | EGFRERBB2LMNAHPGDMEN1 | |
| SCHEMBL4635253 | 0.80 | EGFR (0.48) | EGFRERBB2LMNAHPGDMEN1 | |
| SCHEMBL4635255 | 0.80 | EGFR (0.48) | EGFRERBB2LMNAHPGDMEN1 | |
| SCHEMBL4132690 | 0.79 | EGFR (0.54) | EGFRERBB2PKMLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934192-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | Torrent Pharmaceuticals Ltd (IN) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007032028-A1 | THIAZOLINONES AND OXAZOLINONES AND THEIR USE AS PTP1B INHIBITORS | TORRENT PHARMACEUTICALS LTD. (IN) | 2007-03-22 | — | — | WO | disclosed |