Pyrene

Pyrene

SCHEMBL4668494

CC(C)(C)OCCO.c1cc2ccc3cccc4ccc(c1)c2c34

nearest known ligand 0.42

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.42
HPGD P15428 5/20 0.42
HSD17B10 Q99714 5/20 0.42
CYP3A4 P08684 4/20 0.42
TSHR P16473 3/20 0.42
CYP1A2 P05177 3/20 0.42
CYP1A1 P04798 2/20 0.42
CYP1B1 Q16678 2/20 0.42
TDP1 Q9NUW8 2/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
KMT2A Q03164 4/20 0.33
MCHR1 Q99705 2/20 0.33
MEN1 O00255 2/20 0.33
HEXA P06865 1/20 0.33
HEXB P07686 1/20 0.33
RECQL P46063 1/20 0.32
NR1H2 P55055 1/20 0.32
KDM4E B2RXH2 4/20 0.32
MAPT P10636 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyrene SCHEMBL5449410 0.78 ALDH1A1 (0.48) ALDH1A1HPGDHSD17B10CYP3A4TSHR
SCHEMBL35822 0.76
Pyrene SCHEMBL26656756 0.73 ALDH1A1 (0.69) ALDH1A1HPGDHSD17B10CYP3A4TSHR
SCHEMBL27974695 0.73
Ethylene Glycol SCHEMBL27616494 0.73 MAPK1 (0.38) ALDH1A1TSHRKMT2AMEN1
Potassium SCHEMBL31590863 0.73
Pyrene SCHEMBL105723 0.73 ALDH1A1 (0.69) ALDH1A1HPGDHSD17B10CYP3A4TSHR
SCHEMBL28041169 0.73
Fluoride SCHEMBL1629162 0.73
Pyrene SCHEMBL29078946 0.72 ALDH1A1 (0.58) ALDH1A1HPGDHSD17B10CYP3A4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014044461-A2 STABILIZATION OF CAPSULE SYSTEMS IN LAUNDRY DETERGENTS AND OTHER CLEANING PRODUCTS SYMRISE AG (DE) 2014-03-27 WO disclosed
EP-1928992-A1 CONSUMER PRODUCTS HAVING VARYING ODORS Henkel AG & Co. KGaA (DE) 2008-06-11 EP disclosed
WO-2007028479-A1 CONSUMER PRODUCTS HAVING VARYING ODORS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2007-03-15 WO disclosed
EP-1529006-A1 DISPENSER BOTTLE FOR AT LEAST TWO ACTIVE FLUIDS Henkel Kommanditgesellschaft auf Aktien (DE) 2005-05-11 EP disclosed
WO-2004018319-A1 DISPENSER BOTTLE FOR AT LEAST TWO ACTIVE FLUIDS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2004-03-04 WO disclosed