Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 1/20 | 0.48 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 8/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632721 | 0.84 | EGFR (0.57) | HPGDSEGFRALDH1A1KDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL28295069 | 0.82 | EGFR (0.56) | HPGDSEGFRALDH1A1KDM4EKMT2A | |
| SCHEMBL1571550 | 0.79 | ALDH1A1 (0.63) | TRIM24TYRTRIM33ERN1ALDH1A1 | |
| SCHEMBL3428021 | 0.75 | EGFR (0.57) | TRIM24TYRTRIM33HPGDSEGFR | |
| SCHEMBL30979897 | 0.72 | EGFR (0.57) | HPGDSEGFRALDH1A1NCF1KDM4E | |
| SCHEMBL27801337 | 0.70 | GLA (0.49) | HPGDSALDH1A1KDM4EGAAMAPT | |
| SCHEMBL14074042 | 0.69 | ALDH1A1 (0.54) | TRIM24TYRTRIM33ERN1HPGDS | |
| SCHEMBL28150290 | 0.68 | TYR (0.96) | TRIM24TYRTRIM33ERN1ALDH1A1 | |
| SCHEMBL4785420 | 0.68 | ALDH1A1 (0.53) | TRIM24TYRTRIM33ERN1HPGDS | |
| SCHEMBL3210785 | 0.67 | KDM4E (0.68) | TRIM24TYRTRIM33ERN1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004615-A2 | QUINAZOLINES FOR PDK1 INHIBITION | Novartis AG (CH) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007117607-A9 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2008-03-06 | — | — | WO | disclosed |
| WO-2007117607-A2 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS AG (CH) | 2007-10-18 | — | — | WO | disclosed |