Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | AGXT | P21549 | 2/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.43 |
| ▸ | HTR3B | O95264 | 2/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL777207 | 0.83 | PNMT (0.74) | PNMTTSHRRECQLTAAR1CHRM2 | |
| SCHEMBL14478283 | 0.82 | PNMT (1.00) | PNMTTSHRRECQLTAAR1SIGMAR1 | |
| SCHEMBL30363681 | 0.82 | PNMT (1.00) | PNMTTSHRRECQLTAAR1SIGMAR1 | |
| Ammonia Solution, Strong SCHEMBL27650008 | 0.82 | PNMT (0.71) | PNMTTSHRRECQLTAAR1CHRM2 | |
| SCHEMBL266685 | 0.82 | PNMT (1.00) | PNMTTSHRRECQLTAAR1SIGMAR1 | |
| SCHEMBL20353178 | 0.80 | PNMT (0.69) | PNMTTSHRRECQLTAAR1CHRM2 | |
| SCHEMBL7489958 | 0.80 | PNMT (0.69) | PNMTTSHRRECQLTAAR1CHRM2 | |
| SCHEMBL21076141 | 0.80 | PNMT (0.69) | PNMTTSHRRECQLTAAR1CHRM2 | |
| SCHEMBL2427261 | 0.80 | PNMT (0.69) | PNMTTSHRRECQLTAAR1CHRM2 | |
| SCHEMBL16379378 | 0.80 | PNMT (0.69) | PNMTTSHRRECQLTAAR1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1930308-A1 | Pharmaceutical agents for the treatment of cerebral amyloidosis | NYMOX CORPORATION (CA) | 2008-06-11 | — | — | EP | disclosed |
| EP-0983222-B1 | PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS | NYMOX CORP (CA) | 2007-11-28 | — | — | EP | disclosed |
| US-6518314-B1 | For treating cerebral amyloidosis; compounds that impede the transformation of dense microspheres (DMS) into amyloid | NYMOX CORPORATION (CA) | 2003-02-11 | — | — | US | disclosed |
| US-6130221-A | ALZHEIMERS | NYMOX CORPORATION (CA) | 2000-10-10 | — | — | US | disclosed |
| EP-0983222-A1 | PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS | NYMOX CORPORATION (CA) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998052898-A9 | PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS | NYMOX CORP (CA) | 1999-04-01 | — | — | WO | disclosed |
| WO-1998052898-A1 | PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS | NYMOX CORPORATION (CA) | 1998-11-26 | — | — | WO | disclosed |