Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.39 |
| ▸ | ULK1 | O75385 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 9/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 9/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 9/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4352254 | 0.85 | PIK3CA (0.52) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL4350381 | 0.77 | PIK3CA (0.67) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL4352259 | 0.76 | PIK3CA (0.48) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL13517721 | 0.69 | MEN1 (0.45) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL4345475 | 0.69 | PIK3CA (0.58) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL13518820 | 0.68 | PIK3CA (0.40) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL4350052 | 0.67 | PIK3CA (0.54) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL4344990 | 0.66 | PIK3CA (0.54) | PIK3CAMAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL21497189 | 0.66 | ULK1 (0.43) | ULK1CNR2EGFRIKBKBEPHX2 | |
| SCHEMBL4346394 | 0.66 | PIK3CA (0.64) | PIK3CAMAPK1MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1990342-A1 | Pyridopyrazine Derivatives, Process of Manufacturing and Uses thereof | AEterna Zentaris GmbH (DE) | 2008-11-12 | — | — | EP | disclosed |