Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 11/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | NEK4 | P51957 | 2/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.40 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.40 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | AKT2 | P31751 | 2/20 | 0.40 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4669040 | 1.00 | AKT1 (0.47) | AKT1RPS6KB1MAPK1RPS6KA5GSK3B | |
| SCHEMBL4667583 | 0.84 | RPS6KB1 (0.44) | AKT1RPS6KB1MAPK1RPS6KA5GSK3B | |
| SCHEMBL4667594 | 0.84 | RPS6KB1 (0.44) | AKT1RPS6KB1MAPK1RPS6KA5GSK3B | |
| SCHEMBL4668041 | 0.83 | GSK3B (0.43) | AKT1RPS6KB1MAPK1GSK3BROCK1 | |
| SCHEMBL4668044 | 0.83 | GSK3B (0.43) | AKT1RPS6KB1MAPK1GSK3BROCK1 | |
| SCHEMBL4667866 | 0.83 | GPR88 (0.42) | RPS6KB1MAPK1ROCK1ROCK2AURKA | |
| SCHEMBL4667861 | 0.83 | GPR88 (0.42) | RPS6KB1MAPK1ROCK1ROCK2AURKA | |
| SCHEMBL15304791 | 0.83 | GPR88 (0.42) | RPS6KB1MAPK1ROCK1ROCK2AURKA | |
| SCHEMBL4667756 | 0.82 | MAPK1 (0.46) | MAPK1ROCK1ROCK2AURKAAURKB | |
| SCHEMBL4667763 | 0.82 | MAPK1 (0.46) | MAPK1ROCK1ROCK2AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1980561-B1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-10-09 | — | — | EP | claimed |
| EP-1980561-A1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-10-15 | — | — | EP | claimed |
| EP-1980561-B1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-10-09 | — | — | EP | disclosed |
| EP-1980561-A1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-10-15 | — | — | EP | disclosed |