Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3451926 | 0.99 | PDE4B (0.51) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3452263 | 0.84 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3451264 | 0.83 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4C | |
| Hydrochloric Acid SCHEMBL3451257 | 0.82 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3452620 | 0.82 | PDE4B (0.58) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL14250130 | 0.80 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL19155628 | 0.79 | PDE4B (0.54) | PDE4BPDE4D | |
| SCHEMBL8218538 | 0.77 | PDE4B (0.46) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL14249063 | 0.77 | PDE4B (0.47) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6027642 | 0.74 | PDE4D (0.74) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716133-B1 | 2-(PIPERIDIN-4-YL)-4,5-DIHYDRO-2H-PYRIDAZIN-3-ONE DERIVATIVES AS PDE4 INHIBITORS | NYCOMED GMBH (DE) | 2008-03-26 | — | — | EP | claimed |