Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.79 |
| ▸ | PDE4A | P27815 | 1/20 | 0.79 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.79 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.79 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3451767 | 0.88 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL2324457 | 0.87 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DPKM | |
| SCHEMBL3452374 | 0.86 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL6031273 | 0.86 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4DPKM | |
| SCHEMBL3450802 | 0.85 | PDE4B (0.69) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL3453181 | 0.85 | PDE4B (0.78) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL4672854 | 0.84 | PDE4B (0.84) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL2324930 | 0.83 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DPKM | |
| SCHEMBL3450814 | 0.82 | PDE4B (0.77) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL3451607 | 0.82 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716133-B1 | 2-(PIPERIDIN-4-YL)-4,5-DIHYDRO-2H-PYRIDAZIN-3-ONE DERIVATIVES AS PDE4 INHIBITORS | NYCOMED GMBH (DE) | 2008-03-26 | — | — | EP | claimed |
| EP-1716133-B1 | 2-(PIPERIDIN-4-YL)-4,5-DIHYDRO-2H-PYRIDAZIN-3-ONE DERIVATIVES AS PDE4 INHIBITORS | NYCOMED GMBH (DE) | 2008-03-26 | — | — | EP | disclosed |