Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.84 |
| ▸ | PDE4A | P27815 | 1/20 | 0.84 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.84 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.84 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3451767 | 0.92 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL4670367 | 0.85 | PDE4B (0.73) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL3451607 | 0.85 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL3450814 | 0.84 | PDE4B (0.77) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL4669096 | 0.84 | PDE4B (0.79) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL3453181 | 0.83 | PDE4B (0.78) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL3453010 | 0.82 | PDE4B (0.73) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3450802 | 0.81 | PDE4B (0.69) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL3452374 | 0.79 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL2325252 | 0.78 | PDE4B (0.75) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716133-B1 | 2-(PIPERIDIN-4-YL)-4,5-DIHYDRO-2H-PYRIDAZIN-3-ONE DERIVATIVES AS PDE4 INHIBITORS | NYCOMED GMBH (DE) | 2008-03-26 | — | — | EP | claimed |