Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.50 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3106923 | 0.86 | TSHR (0.53) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL973774 | 0.84 | HSD11B1 (0.56) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL27389439 | 0.81 | HSD11B1 (0.44) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL18260026 | 0.79 | TSHR (0.44) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL27683261 | 0.78 | AKR1C1 (0.63) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL6161497 | 0.77 | TSHR (0.51) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL971790 | 0.77 | TSHR (0.65) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL6543780 | 0.75 | TSHR (0.63) | OPRD1OPRK1TSHRALOX15ATM | |
| Toluene SCHEMBL27551679 | 0.75 | TSHR (0.38) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL972474 | 0.74 | TSHR (0.65) | OPRD1OPRK1TSHRALOX15ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101351464-A | 8-[bis-(2-chloro-phenyl)-methyl]-3-phenyl-8-aza-bicyclo [3.2.1] octane-3-carboxylic acid amide as ligand for the nociceptin receptor ORL-1 | SCHERING CORP (US) | 2009-01-21 | — | — | CN | disclosed |
| EP-1951720-A1 | 8-[BIS-(2-CHLORO-PHENYL)-METHYL]-3-PHENYL-8-AZA-BICYCLO [3.2.1]OCTANE-3-CARBOXYLIC ACID AMIDE AS LIGAND FOR THE NOCICEPTIN RECEPTOR ORL-1 | SCHERING CORPORATION (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007050719-A1 | 8-[BIS-(2-CHLORO-PHENYL)-METHYL]-3-PHENYL-8-AZA-BICYCLO [3.2.1] OCTANE-3-CARBOXYLIC ACID AMIDE AS LIGAND FOR THE NOCICEPTIN RECEPTOR ORL-1 | SCHERING CORPORATION (US) | 2007-05-03 | — | — | WO | disclosed |