Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 9/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.45 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.45 |
| ▸ | ESRRA | P11474 | 1/20 | 0.42 |
| ▸ | P4HB | P07237 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2094284 | 0.89 | ALDH1A1 (0.63) | ALDH1A1KDM4EUSP2ARIMPDH2 | |
| SCHEMBL2635720 | 0.84 | CA12 (0.48) | ARIMPDH2IMPDH1 | |
| SCHEMBL29804271 | 0.80 | MAOB (0.55) | ALDH1A1ARP4HBEGFRGUSB | |
| SCHEMBL459931 | 0.80 | MAOB (0.55) | ALDH1A1ARP4HBEGFRGUSB | |
| SCHEMBL388024 | 0.80 | AR (0.51) | ALDH1A1ARP4HB | |
| Methyl Alcohol SCHEMBL27451617 | 0.79 | AR (0.50) | ALDH1A1ARP4HB | |
| SCHEMBL24476682 | 0.78 | AR (0.54) | ALDH1A1KDM4EUSP2ARPGR | |
| SCHEMBL2793117 | 0.77 | ALDH1A1 (0.58) | ALDH1A1KDM4EUSP2ARIMPDH2 | |
| SCHEMBL16951586 | 0.77 | AR (0.49) | ALDH1A1KDM4EUSP2ARIMPDH2 | |
| SCHEMBL16950438 | 0.77 | ALDH1A1 (0.58) | ALDH1A1KDM4EUSP2ARPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893619-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTMIAS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006135316-A1 | New oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |