Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 11/20 | 0.63 |
| ▸ | RARG | P13631 | 11/20 | 0.63 |
| ▸ | RARA | P10276 | 10/20 | 0.63 |
| ▸ | RXRA | P19793 | 13/20 | 0.56 |
| ▸ | RXRB | P28702 | 2/20 | 0.53 |
| ▸ | RXRG | P48443 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7212228 | 1.00 | RARB (0.63) | RARBRARGRARARXRARXRB | |
| SCHEMBL4669370 | 1.00 | RARB (0.63) | RARBRARGRARARXRARXRB | |
| SCHEMBL10842686 | 1.00 | RARB (0.63) | RARBRARGRARARXRARXRB | |
| SCHEMBL10842696 | 1.00 | RARB (0.63) | RARBRARGRARARXRARXRB | |
| SCHEMBL7212226 | 1.00 | RARB (0.63) | RARBRARGRARARXRARXRB | |
| SCHEMBL7213560 | 0.99 | RARB (0.64) | RARBRARGRARARXRARXRB | |
| SCHEMBL7213554 | 0.99 | RARB (0.64) | RARBRARGRARARXRARXRB | |
| SCHEMBL7062512 | 0.96 | RARB (0.65) | RARBRARGRARARXRARXRB | |
| SCHEMBL7062517 | 0.96 | RARB (0.65) | RARBRARGRARARXRARXRB | |
| SCHEMBL14017859 | 0.91 | RARB (0.68) | RARBRARGRARARXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641759-B1 | Use of aromatic carboxylic derivatives for the preparation of drugs | HOFFMANN LA ROCHE (CH) | 1998-12-09 | — | — | EP | claimed |
| US-5700836-A | TOPICALLY ADMINISTERING TO TREAT PHOTODAMAGED SKIN | HOFFMANN-LA ROCHE INC. (US) | 1997-12-23 | — | — | US | claimed |
| EP-0641759-A1 | Aromatic carboxylic acid derivatives, their preparation and drugs containing these derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-03-08 | — | — | EP | claimed |
| JP-7112952-A | — | — | None | — | — | JP | disclosed |
| EP-1324970-B1 | RETINOIDS FOR THE TREATMENT OF EMPHYSEMA | HOFFMANN LA ROCHE (CH) | 2008-11-05 | — | — | EP | disclosed |
| EP-1324970-B1 | RETINOIDS FOR THE TREATMENT OF EMPHYSEMA | HOFFMANN LA ROCHE (CH) | 2008-11-05 | — | — | EP | disclosed |
| EP-1935869-A1 | Retinoids for the treatment of emphysema | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-25 | — | — | EP | disclosed |
| US-6777418-B2 | FOR TREATING OR PREVENTING EMPHYSEMA, CANCER AND DERMATOLOGICAL DISORDERS | SYNTEX (U.S.A.) LLC | 2004-08-17 | — | — | US | disclosed |
| US-6610877-B1 | Treating photo and/or age damaged skin | HOFFMAN-LA ROCHE INC. | 2003-08-26 | — | — | US | disclosed |
| EP-0817625-B1 | COMPOSITIONS FOR TREATMENT OF PHOTODAMAGED SKIN COMPRISING AN RAR-ALPHA ANTAGONIST AND A MULTI-SELECTIVE RETINOID | HOFFMANN LA ROCHE (CH) | 2003-05-21 | — | — | EP | disclosed |
| US-20020082265-A1 | For treating or preventing emphysema, cancer and dermatological disorders | SYNTEX (U.S.A.) LLC | 2002-06-27 | — | — | US | disclosed |
| EP-0641759-B1 | Use of aromatic carboxylic derivatives for the preparation of drugs | HOFFMANN LA ROCHE (CH) | 1998-12-09 | — | — | EP | disclosed |
| EP-0817625-A2 | COMPOSITIONS FOR TREATMENT OF PHOTODAMAGED SKIN COMPRISING AN RAR-ALPHA ANTAGONIST AND A MULTI-SELECTIVE RETINOID | F. HOFFMANN-LA ROCHE AG (CH) | 1998-01-14 | — | — | EP | disclosed |
| US-5700836-A | TOPICALLY ADMINISTERING TO TREAT PHOTODAMAGED SKIN | HOFFMANN-LA ROCHE INC. (US) | 1997-12-23 | — | — | US | disclosed |
| WO-1996030009-A2 | COMPOSITIONS FOR TREATMENT OF PHOTODAMAGED SKIN COMPRISING AN RAR-ALPHA ANTAGONIST AND A MULTI-SELECTIVE RETINOID | F. HOFFMANN-LA ROCHE AG (CH) | 1996-10-03 | — | — | WO | disclosed |
| JP-H07112952-A | AROMATIC CARBOXYLIC ACID DERIVATIVE AND REMEDY FOR SKIN AND MUCOUS MEMBRANE | F HOFFMANN LA ROCHE AG | 1995-05-02 | — | — | JP | disclosed |
| EP-0641759-A1 | Aromatic carboxylic acid derivatives, their preparation and drugs containing these derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-03-08 | — | — | EP | disclosed |
| US-4578498-A | FOR SKIN DISORDERS; REDUCED TOXICITY | BASF AKTIENGESELLSCHAFT (DE) | 1986-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020082265-A1 | For treating or preventing emphysema, cancer and dermatological disorders | RXRA, RXRG, RXRB | RARB 6/4885RARG 4/4885RARA 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.