Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 8/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 14/20 | 0.42 |
| ▸ | AURKA | O14965 | 10/20 | 0.42 |
| ▸ | TPX2 | Q9ULW0 | 7/20 | 0.42 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | FES | P07332 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4669544 | 0.84 | TEK (0.51) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL581299 | 0.83 | TEK (0.42) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL16268810 | 0.80 | AURKB (0.56) | TEKAURKBAURKATPX2ULK1 | |
| SCHEMBL14428349 | 0.78 | AURKB (0.57) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL4666642 | 0.77 | TEK (0.45) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL4798744 | 0.76 | TEK (0.46) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL580014 | 0.74 | AURKB (0.73) | TEKAURKBAURKATPX2KDR | |
| SCHEMBL4782599 | 0.73 | AURKA (0.44) | TEKAURKBAURKATPX2ULK1 | |
| SCHEMBL4668256 | 0.73 | AURKA (0.38) | TEKAURKBAURKATPX2MAPK14 | |
| SCHEMBL4668268 | 0.72 | AURKB (0.37) | TEKAURKBAURKATPX2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087276-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2007-08-02 | — | — | WO | disclosed |