Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.38 |
| ▸ | TPX2 | Q9ULW0 | 3/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668268 | 0.84 | AURKB (0.37) | AURKAAURKBTPX2PDE10ATEK | |
| SCHEMBL4668233 | 0.80 | AURKA (0.37) | AURKAAURKBTPX2PDE10ATEK | |
| SCHEMBL4794734 | 0.76 | FEN1 (0.35) | PDE10AMAPT | |
| SCHEMBL4668559 | 0.75 | BTK (0.36) | PDE10AALDH1A1MAPT | |
| SCHEMBL581233 | 0.74 | AURKB (0.41) | AURKAAURKBTPX2PDE10ATEK | |
| SCHEMBL4782599 | 0.74 | AURKA (0.44) | AURKAAURKBTPX2PDE10ATEK | |
| SCHEMBL16268810 | 0.73 | AURKB (0.56) | AURKAAURKBTPX2PDE10ATEK | |
| SCHEMBL4669547 | 0.73 | TEK (0.44) | AURKAAURKBTPX2TEKMAPK14 | |
| SCHEMBL4669544 | 0.73 | TEK (0.51) | AURKAAURKBTPX2TEK | |
| SCHEMBL4668530 | 0.71 | USP2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984353-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087276-A1 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2007-08-02 | — | — | WO | disclosed |