Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL985355 | 0.93 | TSHR (0.58) | TSHRMTNR1BMEN1KMT2ATRPV1 | |
| SCHEMBL985807 | 0.92 | TSHR (0.47) | TSHRMTNR1BMEN1KMT2ATRPV1 | |
| SCHEMBL987520 | 0.91 | MEN1 (0.45) | TSHRMTNR1BMEN1KMT2ATRPV1 | |
| SCHEMBL985641 | 0.85 | CA1 (0.54) | TSHRMTNR1BTRPV1CA1CA2 | |
| SCHEMBL4671224 | 0.84 | MTNR1B (0.49) | TSHRMTNR1BMEN1KMT2ATRPV1 | |
| SCHEMBL986456 | 0.84 | EDNRA (0.49) | TSHRMTNR1BMEN1KMT2ATRPV1 | |
| SCHEMBL985851 | 0.84 | MTNR1B (0.56) | TSHRMTNR1BMEN1KMT2ACA1 | |
| SCHEMBL983323 | 0.83 | CA1 (0.47) | MTNR1BCA1CA2CA9CA14 | |
| SCHEMBL986059 | 0.83 | TRPV1 (0.42) | TSHRMEN1KMT2ATRPV1SMN1; SMN2 | |
| SCHEMBL4673800 | 0.83 | MTNR1B (0.52) | TSHRMTNR1BMEN1KMT2ATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732898-B1 | TETRAHYDROISOQUINOLINE- AND TETRAHYDROBENZAZEPINE DERIVATIVES AS IGF-1R INHIBITORS | ANALYTECON SA (CH) | 2008-01-23 | — | — | EP | claimed |
| EP-1732898-B1 | TETRAHYDROISOQUINOLINE- AND TETRAHYDROBENZAZEPINE DERIVATIVES AS IGF-1R INHIBITORS | ANALYTECON SA (CH) | 2008-01-23 | — | — | EP | disclosed |