Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 7/20 | 0.88 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.88 |
| ▸ | CHRM5 | P08912 | 7/20 | 0.88 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.88 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.88 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.88 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.88 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.88 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.88 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.88 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL467380 | 0.94 | CHRM2 (1.00) | CHRM2CHRM4CHRM5CHRM3ADRA2A | |
| Oxalic Acid SCHEMBL10419476 | 0.73 | CHRM2 (0.72) | CHRM2CHRM4CHRM5CHRM3CHRM1 | |
| Oxalic Acid SCHEMBL10419473 | 0.73 | CHRM2 (0.72) | CHRM2CHRM4CHRM5CHRM3CHRM1 | |
| Oxalic Acid SCHEMBL10418823 | 0.70 | CHRM2 (0.67) | CHRM2CHRM4CHRM5CHRM3CHRM1 | |
| Oxalic Acid SCHEMBL10418825 | 0.70 | CHRM2 (0.67) | CHRM2CHRM4CHRM5CHRM3CHRM1 | |
| Oxalic Acid SCHEMBL9404300 | 0.69 | CHRM2 (0.56) | CHRM2CHRM4CHRM5CHRM3CHRM1 | |
| SCHEMBL298670 | 0.68 | CHRM2 (0.49) | CHRM2CHRM4CHRM5CHRM3ADRA2A | |
| SCHEMBL12951373 | 0.66 | SIGMAR1 (0.50) | CHRM2CHRM4CHRM5CHRM3ADRA2A | |
| SCHEMBL12171507 | 0.65 | NPC1 (0.69) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL12171882 | 0.65 | NPC1 (0.69) | NPC1RAB9ACASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2600863-B1 | USE OF SIGMA LIGANDS IN OPIOID-INDUCED HYPERALGESIA | ESTEVE LABOR DR (ES) | 2018-03-28 | — | — | EP | disclosed |
| EP-2646025-B1 | USE OF SIGMA LIGANDS IN BONE CANCER PAIN | ESTEVE LABOR DR (ES) | 2017-03-15 | — | — | EP | disclosed |
| EP-2531191-B1 | Sigma ligands for use in the prevention and/or treatment of postoperative pain | ESTEVE LABOR DR (ES) | 2016-03-30 | — | — | EP | disclosed |
| EP-2571501-B1 | SIGMA LIGANDS FOR THE PREVENTION AND/OR TREATMENT OF EMESIS INDUCED BY CHEMOTHERAPY OR RADIOTHERAPY | ESTEVE LABOR DR (ES) | 2016-03-02 | — | — | EP | disclosed |
| EP-2460519-A1 | Use of sigma ligands in bone cancer pain | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2012-06-06 | — | — | EP | disclosed |
| EP-2415471-A1 | Use of sigma ligands in opioid-induced hyperalgesia | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2012-02-08 | — | — | EP | disclosed |
| EP-2388005-A1 | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2011-11-23 | — | — | EP | disclosed |
| EP-2353598-A1 | Sigma ligands for use in the prevention and/or treatment of postoperative pain | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2011-08-10 | — | — | EP | disclosed |