Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.59 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18157927 | 0.86 | MAOA (0.41) | MAOAMAOBMAPKAPK2LMNASMN1; SMN2 | |
| SCHEMBL10824984 | 0.82 | MAPT (0.43) | MAOAMAOBMAPKAPK2LMNASMN1; SMN2 | |
| SCHEMBL13777196 | 0.81 | MAOA (0.73) | MAOAMAOBMAPKAPK2LMNASMN1; SMN2 | |
| SCHEMBL28853969 | 0.79 | MAOA (0.52) | MAOAMAOBMAPKAPK2LMNASMN1; SMN2 | |
| SCHEMBL9389169 | 0.79 | — | — | |
| SCHEMBL3850026 | 0.77 | AHR (0.56) | MAOAMAOBLMNASMN1; SMN2NPC1 | |
| SCHEMBL88260 | 0.77 | MAOA (0.59) | MAOAMAOBMAPKAPK2LMNASMN1; SMN2 | |
| SCHEMBL8815928 | 0.77 | MAOA (0.59) | MAOAMAOBMAPKAPK2LMNASMN1; SMN2 | |
| SCHEMBL20984959 | 0.77 | MAOA (0.59) | MAOAMAOBMAPKAPK2LMNASMN1; SMN2 | |
| SCHEMBL11813909 | 0.77 | MAOA (0.59) | MAOAMAOBMAPKAPK2LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896467-A2 | TRICYCLIC OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006138528-A2 | TRICYCLIC OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V (BE) | 2006-12-28 | — | — | WO | disclosed |