Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.53 |
| ▸ | TTK | P33981 | 5/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3535778 | 0.86 | HTR6 (0.53) | HTR6TTKMAPK8HTR2BAKR1B1 | |
| SCHEMBL3531858 | 0.85 | HTR6 (0.52) | HTR6TTKMAPK8HTR2BAKR1B1 | |
| SCHEMBL3531546 | 0.85 | HTR6 (0.52) | HTR6TTKMAPK8HTR2BAKR1B1 | |
| SCHEMBL8239424 | 0.84 | HTR6 (0.53) | HTR6TTKMAPK8AKR1B1 | |
| SCHEMBL3531523 | 0.84 | HTR6 (0.52) | HTR6TTKMAPK8 | |
| SCHEMBL3529039 | 0.84 | HTR6 (0.58) | HTR6TTKMAPK8 | |
| SCHEMBL3529991 | 0.84 | HTR6 (0.53) | HTR6TTKMAPK8AKR1B1 | |
| Cerlapirdine SCHEMBL3534330 | 0.84 | HTR6 (0.71) | HTR6HTR2C | |
| Cerlapirdine SCHEMBL29375645 | 0.84 | HTR6 (0.71) | HTR6HTR2C | |
| SCHEMBL3535047 | 0.83 | HTR6 (0.51) | HTR6TTKMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931640-A2 | SUBSTITUTED-3-SULFONYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth a Corporation of the State of Delaware (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007021711-A2 | SUBSTITUTED-3-SULFONYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2007-02-22 | — | — | WO | disclosed |