Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR6 | P43657 | 2/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.35 |
| ▸ | LPAR4 | Q99677 | 2/20 | 0.35 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.35 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.35 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9611250 | 1.00 | LPAR6 (0.35) | LPAR6LPAR1LPAR4LPAR5LPAR2 | |
| SCHEMBL14643062 | 0.87 | LPAR6 (0.38) | LPAR6LPAR1LPAR4LPAR5LPAR2 | |
| SCHEMBL7777378 | 0.84 | — | — | |
| SCHEMBL7776041 | 0.83 | TSHR (0.41) | LPAR1LPAR2LPAR3ALDH1A1TSHR | |
| SCHEMBL6658678 | 0.82 | ALDH1A1 (0.46) | LPAR6LPAR1LPAR4LPAR5LPAR2 | |
| SCHEMBL4847179 | 0.82 | MEN1 (0.35) | LPAR6LPAR1LPAR4LPAR5LPAR2 | |
| SCHEMBL14000853 | 0.82 | ALDH1A1 (0.33) | LPAR6LPAR1LPAR4LPAR5LPAR2 | |
| SCHEMBL7771270 | 0.82 | ALDH1A1 (0.33) | LPAR6LPAR1LPAR4LPAR5LPAR2 | |
| SCHEMBL10592766 | 0.81 | LPAR1 (0.55) | LPAR6LPAR1LPAR4LPAR5LPAR2 | |
| SCHEMBL14642724 | 0.80 | LPAR1 (0.39) | LPAR6LPAR1LPAR4LPAR5LPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613300-B1 | PHOTOSTABILIZED TOPICAL FORMULATIONS OF KETOPROFEN CONTAINING TWO UV FILTERS | BERLIN CHEMIE AG (DE) | 2008-12-10 | — | — | EP | disclosed |
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| US-5880130-A | TREATMENT OF CELL-PROLIFERATION DISEASES | ZENECA LIMITED (GB) | 1999-03-09 | — | — | US | disclosed |
| EP-0733045-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015952-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |