Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.74 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.65 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.65 |
| ▸ | PTPN22 | Q9Y2R2 | 5/20 | 0.65 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.64 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.64 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.64 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | MMP14 | P50281 | 1/20 | 0.64 |
| ▸ | DUSP3 | P51452 | 3/20 | 0.63 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.63 |
| ▸ | PPM1A | P35813 | 1/20 | 0.63 |
| ▸ | PTPN9 | P43378 | 1/20 | 0.63 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.63 |
| ▸ | PTPN18 | Q99952 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4670363 | 1.00 | MEN1 (0.74) | MEN1KMT2ADNMT1PSMD14PTPN22 | |
| SCHEMBL4667634 | 0.92 | PTPN22 (0.66) | MEN1KMT2ADNMT1PSMD14PTPN22 | |
| SCHEMBL4667632 | 0.92 | PTPN22 (0.66) | MEN1KMT2ADNMT1PSMD14PTPN22 | |
| SCHEMBL4669054 | 0.89 | ALDH1A1 (0.78) | MEN1KMT2ADNMT1PSMD14PTPN22 | |
| SCHEMBL4669050 | 0.89 | ALDH1A1 (0.78) | MEN1KMT2ADNMT1PSMD14PTPN22 | |
| SCHEMBL4669020 | 0.88 | CSNK2A2 (0.65) | MEN1KMT2ADNMT1PSMD14PTPN22 | |
| SCHEMBL4669022 | 0.88 | CSNK2A2 (0.65) | MEN1KMT2ADNMT1PSMD14PTPN22 | |
| SCHEMBL4669049 | 0.88 | DNMT1 (0.74) | MEN1KMT2ADNMT1PSMD14PTPN22 | |
| SCHEMBL4669053 | 0.88 | DNMT1 (0.74) | MEN1KMT2ADNMT1PSMD14PTPN22 | |
| SCHEMBL4667559 | 0.86 | CDC25B (0.80) | MEN1KMT2ADNMT1PSMD14PTPN22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2000140-A1 | Use of derivatives of 3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine or of 3-oxo-2,3-dihydro-5H-imidazolo[3,2-a]pyrimidine for the preparation of pharmaceutical compositions intended for the treatment of cancer | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2008-12-10 | — | — | EP | disclosed |