Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NCEH1 | Q6PIU2 | 2/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672855 | 0.81 | NCEH1 (0.38) | LMNANCEH1HPGDMEN1NPC1 | |
| SCHEMBL4672458 | 0.80 | ALDH1A1 (0.53) | ALDH1A1LMNAL3MBTL1NCEH1NR1H4 | |
| SCHEMBL4673276 | 0.80 | NCEH1 (0.43) | ALDH1A1LMNAL3MBTL1NCEH1HPGD | |
| SCHEMBL4673574 | 0.77 | NCEH1 (0.38) | ALDH1A1LMNANCEH1HPGDNPC1 | |
| SCHEMBL4673581 | 0.76 | NCEH1 (0.37) | LMNANCEH1HPGDMEN1NPC1 | |
| SCHEMBL4673571 | 0.76 | NCEH1 (0.35) | NCEH1HPGDMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL4676179 | 0.75 | NCEH1 (0.40) | LMNAL3MBTL1NCEH1HPGDMEN1 | |
| SCHEMBL4673960 | 0.75 | NCEH1 (0.40) | LMNAL3MBTL1NCEH1HPGDMAPT | |
| SCHEMBL4672861 | 0.75 | ROCK1 (0.41) | NCEH1MEN1NPC1MAPTRAB9A | |
| SCHEMBL6585048 | 0.74 | PTPN1 (0.42) | L3MBTL1MEN1MAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397341-B1 | 6-(ARYL-AMIDO OR ARYL-AMIDOMETHYL)-NAPHTHALEN-2-YLOXY-ACIDIC DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 (PAI-1) | WYETH CORP (US) | 2008-08-06 | — | — | EP | claimed |