Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.77 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.77 |
| ▸ | GSK3A | P49840 | 3/20 | 0.77 |
| ▸ | GSK3B | P49841 | 3/20 | 0.77 |
| ▸ | EGFR | P00533 | 2/20 | 0.77 |
| ▸ | INSR | P06213 | 2/20 | 0.77 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.77 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.77 |
| ▸ | FLT1 | P17948 | 1/20 | 0.77 |
| ▸ | FLT4 | P35916 | 1/20 | 0.77 |
| ▸ | CDK1 | P06493 | 3/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4670174 | 0.87 | KDR (1.00) | KDRFGFR2GSK3AGSK3BEGFR | |
| SCHEMBL4670165 | 0.87 | CDK1 (1.00) | KDRFGFR2GSK3AGSK3BEGFR | |
| SCHEMBL4670452 | 0.85 | KDR (1.00) | KDRFGFR2GSK3AGSK3BEGFR | |
| SCHEMBL4672445 | 0.82 | KDR (0.73) | KDRFGFR2GSK3AGSK3BEGFR | |
| SCHEMBL4670527 | 0.82 | KDR (1.00) | KDRFGFR2GSK3AGSK3BEGFR | |
| SCHEMBL4670192 | 0.79 | KDR (0.70) | KDRFGFR2GSK3AGSK3BEGFR | |
| SCHEMBL4672229 | 0.78 | CDK1 (0.66) | KDRFGFR2GSK3AGSK3BEGFR | |
| SCHEMBL14017779 | 0.78 | KDR (0.80) | KDRFGFR2GSK3AGSK3BEGFR | |
| SCHEMBL2856333 | 0.78 | KDR (1.00) | KDRFGFR2GSK3AGSK3BEGFR | |
| SCHEMBL14017788 | 0.77 | KDR (0.83) | KDRFGFR2GSK3AGSK3BEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1330452-B1 | PYRAZINE DERIVATIVES AS MODULATORS OF TYROSINE KINASES | ORTHO MCNEIL PHARM INC (US) | 2008-11-26 | — | — | EP | disclosed |