Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 6/20 | 0.66 |
| ▸ | KDR | P35968 | 18/20 | 0.65 |
| ▸ | EGFR | P00533 | 2/20 | 0.64 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.64 |
| ▸ | GSK3A | P49840 | 2/20 | 0.64 |
| ▸ | GSK3B | P49841 | 2/20 | 0.64 |
| ▸ | INSR | P06213 | 1/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.64 |
| ▸ | FLT1 | P17948 | 1/20 | 0.64 |
| ▸ | FLT4 | P35916 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672445 | 0.81 | KDR (0.73) | CDK1KDREGFRFGFR2GSK3A | |
| SCHEMBL4670165 | 0.80 | CDK1 (1.00) | CDK1KDREGFRFGFR2GSK3A | |
| SCHEMBL2856333 | 0.79 | KDR (1.00) | CDK1KDREGFRFGFR2GSK3A | |
| SCHEMBL4670503 | 0.78 | KDR (0.77) | CDK1KDREGFRFGFR2GSK3A | |
| SCHEMBL14018403 | 0.78 | KDR (0.57) | CDK1KDREGFR | |
| SCHEMBL4670174 | 0.78 | KDR (1.00) | CDK1KDREGFRFGFR2GSK3A | |
| SCHEMBL4670452 | 0.76 | KDR (1.00) | CDK1KDREGFRFGFR2GSK3A | |
| SCHEMBL4670192 | 0.74 | KDR (0.70) | CDK1KDREGFRFGFR2GSK3A | |
| SCHEMBL14017623 | 0.73 | TRPV1 (0.47) | KDREGFR | |
| SCHEMBL4670527 | 0.72 | KDR (1.00) | CDK1KDREGFRFGFR2GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1330452-B1 | PYRAZINE DERIVATIVES AS MODULATORS OF TYROSINE KINASES | ORTHO MCNEIL PHARM INC (US) | 2008-11-26 | — | — | EP | disclosed |
| EP-1330452-A2 | PYRAZINE DERIVATIVES AS MODULATORS OF TYROSINE KINASES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-07-30 | — | — | EP | disclosed |
| WO-2002024681-A2 | PYRAZINE DERIVATIVES AS MODULATORS OF TYROSINE KINASES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-03-28 | — | — | WO | disclosed |