Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 12/20 | 0.64 |
| ▸ | AURKA | O14965 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
| ▸ | RET | P07949 | 1/20 | 0.64 |
| ▸ | MET | P08581 | 1/20 | 0.64 |
| ▸ | KIT | P10721 | 1/20 | 0.64 |
| ▸ | SRC | P12931 | 1/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 1/20 | 0.64 |
| ▸ | FLT3 | P36888 | 1/20 | 0.64 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.64 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.64 |
| ▸ | MERTK | Q12866 | 1/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.64 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.64 |
| ▸ | ETV6 | P41212 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL467824 | 0.91 | AXL (0.77) | AXLAURKAEGFRRETMET | |
| SCHEMBL467825 | 0.91 | AXL (0.77) | AXLAURKAEGFRRETMET | |
| SCHEMBL30121612 | 0.91 | AXL (0.77) | AXLAURKAEGFRRETMET | |
| SCHEMBL467608 | 0.91 | AXL (0.74) | AXLAURKAEGFRRETMET | |
| SCHEMBL467730 | 0.90 | AXL (0.75) | AXLAURKAEGFRRETMET | |
| SCHEMBL467814 | 0.89 | AXL (0.62) | AXLAURKAEGFRRETMET | |
| SCHEMBL467842 | 0.88 | AXL (0.83) | AXLAURKAEGFRRETMET | |
| SCHEMBL30121550 | 0.88 | AXL (0.83) | AXLAURKAEGFRRETMET | |
| SCHEMBL467934 | 0.87 | AXL (0.66) | AXLAURKAEGFRRETMET | |
| SCHEMBL467927 | 0.85 | AXL (0.60) | AXLAURKAEGFRRETMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387395-A1 | AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER | Rigel Pharmaceuticals, Inc. (US) | 2011-11-23 | — | — | EP | disclosed |
| US-8040491-B2 | Exposure method, substrate stage, exposure apparatus, and device manufacturing method | NIKON CORPORATION (JP) | 2011-10-18 | — | — | US | disclosed |
| WO-2010083465-A1 | AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER | RIGEL PHARMACEUTICALS, INC. (US) | 2010-07-22 | — | — | WO | disclosed |