SCHEMBL467825

SCHEMBL467825

Nc1nc(Nc2ccc3c(c2)CC[C@@H](N2CCCC2)CC3)n(-c2cc3c(nn2)-c2ccccc2CCC3)n1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AXL P30530 12/20 0.77
AURKA O14965 1/20 0.77
EGFR P00533 1/20 0.77
RET P07949 1/20 0.77
MET P08581 1/20 0.77
KIT P10721 1/20 0.77
SRC P12931 1/20 0.77
PDGFRA P16234 1/20 0.77
KDR P35968 1/20 0.77
FLT3 P36888 1/20 0.77
TYRO3 Q06418 1/20 0.77
DDR1 Q08345 1/20 0.77
MERTK Q12866 1/20 0.77
AURKB Q96GD4 1/20 0.77
ALK Q9UM73 1/20 0.77
ETV6 P41212 1/20 0.36
JAK2 O60674 1/20 0.35
JAK3 P52333 1/20 0.35
PTK2 Q05397 1/20 0.35
ACHE P22303 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL467824 1.00 AXL (0.77) AXLAURKAEGFRRETMET
SCHEMBL30121612 1.00 AXL (0.77) AXLAURKAEGFRRETMET
SCHEMBL467730 0.99 AXL (0.75) AXLAURKAEGFRRETMET
SCHEMBL467608 0.98 AXL (0.74) AXLAURKAEGFRRETMET
SCHEMBL467934 0.92 AXL (0.66) AXLAURKAEGFRRETMET
SCHEMBL467053 0.91 AXL (0.64) AXLAURKAEGFRRETMET
SCHEMBL468644 0.89 AXL (0.61) AXLAURKAEGFRRETMET
SCHEMBL467927 0.89 AXL (0.60) AXLAURKAEGFRRETMET
SCHEMBL467814 0.89 AXL (0.62) AXLAURKAEGFRRETMET
SCHEMBL467806 0.87 AXL (0.59) AXLAURKAEGFRRETMET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230372337-A1 Combination Therapy Comprising an AXL Inhibitor BERGENBIO ASA (NO) 2023-11-23 US claimed
US-20230250169-A1 AXL Inhibitors for Antiviral Therapy BERGENBIO ASA (NO) 2023-08-10 US claimed
EP-4138823-A1 METHOD OF SELECTING PATIENTS FOR TREATMENT WITH A COMBINATION OF AN AXL INHIBITOR AND AN IMMUNE CHECKPOINT MODULATOR BerGenBio ASA (NO) 2023-03-01 EP claimed
US-11534440-B2 Combination therapy with Axl inhibitor and immune checkpoint modulator or oncolytic virus BERGENBIO ASA (NO) 2022-12-27 US claimed
WO-2021214492-A1 METHOD OF SELECTING PATIENTS FOR TREATMENT WITH A COMBINATION OF AN AXL INHIBITOR AND AN IMMUNE CHECKPOINT MODULATOR BERGENBIO ASA (NO) 2021-10-28 WO claimed
EP-3804723-A1 COMBINATION THERAPY BerGenBio ASA (NO) 2021-04-14 EP claimed
US-20190336500-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER RIGEL PHARMACEUTICALS, INC. 2019-11-07 US claimed
US-20180153888-A1 COMBINATION THERAPY WITH AXL INHIBITOR AND IMMUNE CHECKPOINT MODULATOR OR ONCOLYTIC VIRUS BERGENBIO ASA (NO) 2018-06-07 US claimed
EP-3302481-A1 COMBINATION THERAPY WITH AXL INHIBITOR AND IMMUNE CHECKPOINT MODULATOR OR ONCOLYTIC VIRUS BerGenBio ASA (NO) 2018-04-11 EP claimed
US-20170042891-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER RIGEL PHARMACEUTICALS, INC. 2017-02-16 US claimed
WO-2016193680-A1 COMBINATION THERAPY WITH AXL INHIBITOR AND IMMUNE CHECKPOINT MODULATOR OR ONCOLYTIC VIRUS BERGENBIO AS (NO) 2016-12-08 WO claimed
US-20160339021-A1 USE OF KINASE INHIBTORS BERGENBIO ASA (NO) 2016-11-24 US claimed
EP-2387395-B1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER RIGEL PHARMACEUTICALS INC (US) 2014-10-15 EP claimed
US-20130338161-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER RIGEL PHARMACEUTICALS INC (US) 2013-12-19 US claimed
US-20100196511-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER RIGEL PHARMACEUTICALS, INC. (US) 2010-08-05 US claimed
US-7709482-B2 angiogenesis and/or cell proliferation, carcinoma, myeloid leukemia, endometriosis; inhibitors of the receptor protein tyrosine kinase; N3-(3-cyclopentyl-1,2,3,4,5,6-hexahydrobenzo[d]azocin-8-yl)-1-(6-fluoroquinazolin-4-yl)-1H-1,2,4-triazole-3,5-diamine RIGEL PHARMACEUTICALS, INC. (US) 2010-05-04 US claimed
US-20080188455-A1 POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS RIGEL PHARMACEUTICALS, INC. (US) 2008-08-07 US claimed
US-20230372337-A1 Combination Therapy Comprising an AXL Inhibitor BERGENBIO ASA (NO) 2023-11-23 US disclosed
US-7709482-B2 angiogenesis and/or cell proliferation, carcinoma, myeloid leukemia, endometriosis; inhibitors of the receptor protein tyrosine kinase; N3-(3-cyclopentyl-1,2,3,4,5,6-hexahydrobenzo[d]azocin-8-yl)-1-(6-fluoroquinazolin-4-yl)-1H-1,2,4-triazole-3,5-diamine RIGEL PHARMACEUTICALS, INC. (US) 2010-05-04 US disclosed
US-20080188455-A1 POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS RIGEL PHARMACEUTICALS, INC. (US) 2008-08-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100196511-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER AXL, FLT3, MET AXL 1/4885AURKA 181/4885EGFR 17/4885
US-20190336500-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER AXL, FLT3, MET AXL 1/4885AURKA 181/4885EGFR 17/4885
US-11534440-B2 Combination therapy with Axl inhibitor and immune checkpoint modulator or oncolytic virus AXL, CD274, HAVCR2 AXL 1/4885AURKA 64/4885EGFR 45/4885
US-20230372337-A1 Combination Therapy Comprising an AXL Inhibitor AXL, CD274, CD47 AXL 1/4885AURKA 176/4885EGFR 55/4885
US-20230250169-A1 AXL Inhibitors for Antiviral Therapy FLT3, AXL, SARS1 AXL 2/4885AURKA 436/4885EGFR 81/4885
US-20080188455-A1 POLYCYCLIC HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS AXL, TYRO3, ERBB3 AXL 1/4885AURKA 572/4885EGFR 45/4885
US-20170042891-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER AXL, FLT3, MET AXL 1/4885AURKA 181/4885EGFR 17/4885
US-20160339021-A1 USE OF KINASE INHIBTORS INHA, ERBB2, MAP3K1 AXL 7/4885AURKA 57/4885EGFR 76/4885
US-20130338161-A1 AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER AXL, FLT3, MET AXL 1/4885AURKA 181/4885EGFR 17/4885
US-20180153888-A1 COMBINATION THERAPY WITH AXL INHIBITOR AND IMMUNE CHECKPOINT MODULATOR OR ONCOLYTIC VIRUS AXL, CD274, HAVCR2 AXL 1/4885AURKA 64/4885EGFR 45/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.