Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 14/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17054441 | 0.83 | CNR2 (0.57) | CNR2CNR1NPC1 | |
| SCHEMBL22534570 | 0.81 | HSD17B3 (0.54) | CNR2NPC1 | |
| SCHEMBL8897300 | 0.81 | CNR2 (0.58) | CNR2CNR1NPC1 | |
| SCHEMBL28018427 | 0.77 | CNR2 (0.64) | CNR2CNR1NPC1 | |
| SCHEMBL29677813 | 0.77 | ALDH1A1 (0.68) | CNR2CNR1NPC1 | |
| SCHEMBL2804157 | 0.77 | ALDH1A1 (0.68) | CNR2CNR1NPC1 | |
| SCHEMBL8899005 | 0.76 | CNR2 (0.58) | CNR2CNR1NPC1 | |
| SCHEMBL13320183 | 0.75 | HSD17B3 (0.47) | CNR2NPC1 | |
| SCHEMBL28700254 | 0.74 | POLB (0.45) | CNR2CNR1 | |
| SCHEMBL25515782 | 0.74 | CNR2 (0.54) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9315828-B2 | Prompt nucleic acid delivery carrier composition | Takeuchi, Hirofumi (JP) | 2016-04-19 | — | — | US | disclosed |
| US-9090912-B1 | Nucleic acid complex and nucleic acid-delivering composition | Takeuchi, Hirofumi (JP) | 2015-07-28 | — | — | US | disclosed |
| EP-2405001-B1 | NUCLEIC ACID COMPLEX AND NUCLEIC ACID-DELIVERING COMPOSITION | TAKEUCHI HIROFUMI (JP) | 2015-07-08 | — | — | EP | disclosed |
| EP-2140870-B1 | PROMPT NUCLEIC ACID DELIVERY CARRIER COMPOSITION | OTSUKA PHARMA CO LTD (JP) | 2015-06-24 | — | — | EP | disclosed |
| EP-1946761-B1 | CARRIER COMPOSITION FOR NUCLEIC ACID TRANSPORT | OTSUKA PHARMA CO LTD (JP) | 2013-04-03 | — | — | EP | disclosed |
| US-8338584-B2 | Nucleic acid complex and nucleic acid delivery composition | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-12-25 | — | — | US | disclosed |
| EP-2405001-A1 | NUCLEIC ACID COMPLEX AND NUCLEIC ACID-DELIVERING COMPOSITION | Takeuchi, Hirofumi (JP) | 2012-01-11 | — | — | EP | disclosed |
| US-8030075-B2 | Carrier composition for nucleic acid transport | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2011-10-04 | — | — | US | disclosed |
| EP-2217208-B1 | NUCLEIC ACID COMPLEX AND NUCLEIC ACID DELIVERY COMPOSITION | OTSUKA PHARMA CO LTD (JP) | 2011-08-31 | — | — | EP | disclosed |
| US-20100305190-A1 | NUCLEIC ACID COMPLEX AND NUCLEIC ACID DELIVERY COMPOSITION | Takeuchi, Hirofumi (JP) | 2010-12-02 | — | — | US | disclosed |
| US-20100063131-A1 | PROMPT NUCLEIC ACID DELIVERY CARRIER COMPOSITION | Takeuchi, Hirofumi (JP) | 2010-03-11 | — | — | US | disclosed |
| EP-2140870-A1 | PROMPT NUCLEIC ACID DELIVERY CARRIER COMPOSITION | Otsuka Pharmaceutical Co., Ltd. (JP) | 2010-01-06 | — | — | EP | disclosed |
| US-20090258923-A1 | Carrier Composition for Nucleic Acid Transport | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2009-10-15 | — | — | US | disclosed |
| EP-1946761-A1 | CARRIER COMPOSITION FOR NUCLEIC ACID TRANSPORT | Otsuka Pharmaceutical Co., Ltd. (JP) | 2008-07-23 | — | — | EP | disclosed |