Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KIT | P10721 | 4/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | APLNR | P35414 | 1/20 | 0.50 |
| ▸ | GLP1R | P43220 | 1/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4559263 | 0.86 | TP53 (0.63) | TP53ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL4671180 | 0.84 | KDM4E (0.64) | TP53ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL5956394 | 0.82 | TP53 (0.59) | TP53ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL5474021 | 0.82 | MEN1 (0.76) | TP53ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL7095416 | 0.81 | ALDH1A1 (0.68) | TP53ALDH1A1TSHRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL28550900 | 0.81 | TP53 (0.58) | TP53ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL7095047 | 0.79 | ALDH1A1 (0.67) | TP53ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL6618388 | 0.76 | POLB (0.65) | ALDH1A1MEN1KMT2ANPC1PKM | |
| SCHEMBL13873489 | 0.76 | ALDH1A1 (0.62) | TP53ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL15504601 | 0.75 | TP53 (0.55) | TP53ALDH1A1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |