Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL242610 | 0.85 | ADORA1 (0.52) | ADORA3ADORA1ADORA2BADORA2ARAB9A | |
| SCHEMBL312409 | 0.84 | SLC18A3 (0.50) | ADORA3ADORA1ADORA2BADORA2AMEN1 | |
| Hydrochloric Acid SCHEMBL1653372 | 0.83 | SLC18A3 (0.49) | ADORA3ADORA1ADORA2BADORA2AMEN1 | |
| Hydrochloric Acid SCHEMBL311386 | 0.83 | SLC18A3 (0.49) | ADORA3ADORA1ADORA2BADORA2AMEN1 | |
| SCHEMBL6166041 | 0.81 | SLC18A3 (0.47) | ADORA3ADORA1ADORA2BMEN1KMT2A | |
| SCHEMBL22931042 | 0.81 | ADORA1 (0.49) | ADORA3ADORA1ADORA2BADORA2ARAB9A | |
| SCHEMBL19657007 | 0.80 | ADORA1 (0.48) | ADORA3ADORA1ADORA2BADORA2ARAB9A | |
| Hydrochloric Acid SCHEMBL6806273 | 0.80 | SLC18A3 (0.46) | ADORA3ADORA1ADORA2BMEN1KMT2A | |
| SCHEMBL19657010 | 0.80 | ADORA1 (0.48) | ADORA3ADORA1ADORA2BADORA2ARAB9A | |
| SCHEMBL408754 | 0.79 | NPC1 (0.55) | ADORA3ADORA1ADORA2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |