SCHEMBL4672134

SCHEMBL4672134

CC(C)(C)CC(C)(C)c1ccc(Oc2ccc(C(N)=O)cc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 11/20 0.59
PARP15 Q460N3 4/20 0.59
PARP14 Q460N5 2/20 0.59
PARP4 Q9UKK3 2/20 0.59
ALDH1A1 P00352 1/20 0.59
KMT2A Q03164 1/20 0.59
PARP16 Q8N5Y8 1/20 0.59
PARP11 Q9NR21 1/20 0.59
CYP3A4 P08684 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
PARP3 Q9Y6F1 1/20 0.49
PARP2 Q9UGN5 3/20 0.47
TNKS O95271 1/20 0.47
TNKS2 Q9H2K2 1/20 0.47
SHBG P04278 1/20 0.47
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
PARP1 P09874 1/20 0.47
NPC1 O15118 2/20 0.45
RAB9A P51151 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21628722 0.86 NPC1 (0.63) PARP10PARP15PARP14PARP4ALDH1A1
SCHEMBL480668 0.83 CYP3A4 (0.61) ALDH1A1KMT2ACYP3A4SMN1; SMN2SHBG
SCHEMBL4671943 0.82 PARP10 (0.70) PARP10PARP15PARP14PARP4ALDH1A1
Ethylene Glycol SCHEMBL1832016 0.80 CYP3A4 (0.69) ALDH1A1KMT2ACYP3A4SMN1; SMN2SHBG
SCHEMBL1836425 0.79 CYP3A4 (0.54) KMT2ACYP3A4SMN1; SMN2SHBGMDH1
SCHEMBL4672138 0.78 MAPT (0.71) ALDH1A1KMT2ACYP3A4SMN1; SMN2SHBG
SCHEMBL28472882 0.78 CYP3A4 (0.61) ALDH1A1KMT2ACYP3A4SMN1; SMN2SHBG
SCHEMBL3137816 0.77 PARP10 (1.00) PARP10PARP15PARP14PARP4ALDH1A1
1,4-Butanediol SCHEMBL1592411 0.77 CYP3A4 (0.65) ALDH1A1KMT2ACYP3A4SMN1; SMN2SHBG
SCHEMBL27932707 0.77 SHBG (0.53) CYP3A4SMN1; SMN2SHBGCA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1054881-B1 NOVEL SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA-3 ADRENORECEPTOR AGONISTS BAYER CORP (US) 2008-07-30 EP disclosed
US-6051586-A HYPOGLYCEMIC AGENTS; ANTIDIABETIC AGENTS BAYER CORPORATION (US) 2000-04-18 US disclosed